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Extracellular histones exacerbate heat stroke-induced liver injury by triggering hepatocyte pyroptosis and liver injury via the TLR9-NLRP3 pathway

However, questions about cost remain a barrier for many seeking this therapy

Some patients remain at lower doses (2.5 mg or 5 mg) due to gastrointestinal side effects or insurance restrictions, never reaching the 10 mg or 15 mg doses where maximal efficacy was demonstrated in clinical trials